[(25R)-Spirost-5-en-3β-yl]2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside
Paris saponin V
CAS: 19057-67-1
Molecular Formula: C39H62O12
[(25R)-Spirost-5-en-3β-yl]2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside - Names and Identifiers
[(25R)-Spirost-5-en-3β-yl]2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside - Physico-chemical Properties
| Molecular Formula | C39H62O12 |
| Molar Mass | 722.9 |
| Density | 1.34 |
| Melting Point | 212℃ |
| Boling Point | 838.8±65.0 °C(Predicted) |
| Specific Rotation(α) | - 99.2 (c, 0.21 in Py) |
| Solubility | Soluble in methanol, DMSO, pyridine |
| Appearance | White needle crystal |
| pKa | 12.85±0.70(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| MDL | MFCD16294846 |
| Physical and Chemical Properties | Sources from Zhonglou, lettuce flowers, small flowers, Dioscorea zingiberensis, Mianbi |
[(25R)-Spirost-5-en-3β-yl]2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside - Reference
| Reference Show more | 1. Gao Yan, Li Dewang, et al. Research on UPLC characteristic Atlas of Paris polyphylla in Yunnan [J]. China Food and Drug Administration No. 2019 No.188(09):40-46. 2. Juboya Li Yanmin, Zhu Houda, fangyunge, Wang, Rui, Chen, er, Wu, Gao, Hui, Min, Wang, Zhi, min. On improving the quality standard of Chinese Pharmacopoeia (2020 edition). Chinese Journal of Experimental prescriptions, 2019, 25(19):93-101. 3. Wang Shibao, Cai Yanni, Jia Huimei et al. Determination of seven steroidal saponins in Rhizoma Paridis from different sources by HPLC [J]. Northwest Pharmaceutical Journal, 2017, 32(002):133-138. 4. Wang Shibao, Su Ying, Li Huining et al. Optimization of reflux extraction of steroidal saponins from Rhizoma Paridis by response surface methodology [J]. Shaanxi Agricultural Sciences 2019 065(001):46-52. 5. [IF = 4.36] Chong Jun Zhao et al."Similar mortality response induced by Rhizoma Paridis in zebra fish larvae, cell and rat." J Ethnopharmacol. 2020 Mar;250:112440 6. [IF=3.935] Liangjun Guan et al."Influence of drying process on furostanoside and spirostanoside profiles of Paridis Rhizoma by combination of HPLC, UPLC and UPLC-QTOF-MS/MS analyses."J Pharmaceut Biomed. 2021 Apr;197:113932 7. [IF=2.289] Zhou Shun et al."Anthelmintic efficacy of natural saponins against Gyrodactylus kobayashii in goldfish (Carassius auratus) and their 3D-QSAR analysis."Parasitol Res. 2021 Mar;120(3):1143-1150 |
[(25R)-Spirost-5-en-3β-yl]2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside - Reference Information
| Overview | Paris polyphylla, also known as seborrheum, is the dry rhizome of Paris genus of trillaceae. The analysis of its chemical composition showed that the steroidal saponins contained in the plants of the genus was the main chemical composition. The steroidal saponins contained in Paris polyphylla are the material basis of its efficacy. Recent studies have found that Paridis anti-tumor can achieve anti-tumor effect by blocking tumor angiogenesis. It can not only anti-tumor, but also can reverse tumor drug resistance. The mechanism of killing tumor cells by polyphylum is to induce apoptosis of tumor cells. Paridis saponin V is one of the important monomers of Paridis extract, which has good anti-cancer effect. Paridis saponin monomer V showed good antitumor effect on colon cancer cells in vitro. Compared with oxaliplatin, a commonly used anti-tumor drug, polyphylla saponin V has strong anti-tumor properties on colon cancer cells, and has the potential to become an effective anti-colon cancer drug. figure: Paris polyphylla |
| Anti-tumor advantage | the toxic effect of Rhizoma Paridis saponin on colon cancer cells. Rhizoma Paridis extract V on colon cancer cells Lovo, SW620, SW480, Colo320 have a certain degree of toxicity. The IC50 value calculated by SPSS23. 0 software showed that the saponin v monomer showed dose-dependent toxicity to colon cancer cells and showed good anti-tumor activity. Under the concentration of 2 mg/L, the toxicity of V in the colon cancer cells was better than that of oxaliplatin, which showed good anti-tumor properties. In addition, it not only shows a lower inhibitory concentration on colon cancer cells, but also can kill most tumor cells at a slightly large dose (e. G., 1-4 mg /L), which is superior to oxaliplatin. |
| references | [1] Peng Xiaohui, Tang Jie, Shi Zuxuan, etc. Comparison of in vitro toxic effects of four saponins from Rhizoma Paridis on colon cancer cells [J]. Shandong Medical Journal, 2016, 56(13):13-16. |
| biological activity | Prosapogenin A is A natural product of ginseng, which inhibits STAT3 signaling pathway and glycolysis, induction of apoptosis in human cancer cells in vitro. |
Last Update：2024-04-09 21:54:55
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Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
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